Methanesulfonic Acid → HCID 18318088, compound

Participants

Reaction Conditions

Reaction Steps

Methanesulfonic acid (1.48 gm; 15.4 mmol) was add to the alcohol of Step A (1.07 gm; 2.99 mmol) in TMF at 0° C. The reaction mixture was then warmed to 60° C. and stirred overnight. Water was added and 1N NaOH was added until mixture turned to basic. The aqueous layer was extracted with ethyl acetate (3×100 mL). The organic layer was washed with brine and then dried over magnesium sulfate, filtered and then concentrated to give 0.47 gm of the title compound.

Provenance & Evidence