Acetic Anhydride → HCID 18318073, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 30.2 mmol (6.15 g) of 2,2-dimethyl-6-ethoxy-1,2-dihydroquinoline (prepared according to the procedure described in Steps 1 and 2 of Example 1 starting from 2-chloro-2-methyl-3-butyne) in 45 ml of acetic anhydride is heated at 100° C. under an inert atmosphere for 3 hours. After cooling, the medium is concentrated and the residue is purified by chromatography on silica gel, using a dichloromethane:ethyl acetate mixture 95:5 as eluant, to yield the expected compound.

Provenance & Evidence