Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tert-butyl 4-(4-nitro-2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate → Tert-butyl 4-(4-amino-2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tert-butyl 4-(4-nitro-2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate | HCID 22181018 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Palladium | HCID 23938 | — |
| 생성물 | Tert-butyl 4-(4-amino-2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate | HCID 22180984 | — |
반응 단계
4-(N-(t-butoxycarbonyl)piperidin-4-yl)oxy-3-trifluoromethyl-1-nitrobenzene was dissolved in methanol in the presence of Pd/C. The solution was hydrogenated at 50 psi for 1 hour until hydrogen intake was completed. The catalyst was filtered off and the filtrate was concentrated to afford 4-[(N-(t-butoxycarbonyl)piperidin-4-yl)oxy]-3-trifluoromethylbenzenamine, >95%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06350761B1 |
| 출처 데이터셋 | uspto-grants-2002_02 |
| ORD ID | ord-c133d905142b4d6f9a19f39021fb1752 |
| 출처 메모 | uspto-grants-2002_02 |