HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 22181168, compound → 4-[(1-Methylpiperidin-4-yl)oxy]-3-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 22181168 | HCID 22181168 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Palladium | HCID 23938 | — |
| Product | 4-[(1-Methylpiperidin-4-yl)oxy]-3-(trifluoromethyl)aniline | HCID 22181046 | — |
Reaction Steps
4-(N-methylpiperidin-4-yl)oxy-3-trifluoromethyl-1-nitrobenzene was dissolved in methanol in the presence of Pd/C. The solution was hydrogenated at 50 psi for 1 hour until hydrogen intake was completed. The catalyst was filtered off and the filtrate was concentrated to afford 4-(N-methylpiperidin-4-yl)oxy-3-trifluoromethylbenzenamine, >95%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06350761B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-4cb246c39a594e9eb19deff567f829c9 |
| Source note | uspto-grants-2002_02 |