HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Triphenylphosphoranylidene)acetaldehyde → 3-Cyano-6-((4-methoxybenzyl)oxy)-1-(2-formylethenyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Triphenylphosphoranylidene)acetaldehyde | HCID 75051 | — |
| Reactant | 3-Cyano-6-((4-methoxybenzyl)oxy)benzaldehyde | HCID 18318156 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Cyano-6-((4-methoxybenzyl)oxy)-1-(2-formylethenyl)benzene | HCID 73437155 | 91.1% |
Reaction Steps
A mixture of 3-cyano-6-((4-methoxybenzyl)oxy)benzaldehyde (2.8 g) and (triphenylphosphoranylidene)acetaldehyde (3.5 g) in 40 mL CH2Cl2 was stirred at reflux for 16 hours. The solution was cooled to ambient temperature, concentrated and purified on silica gel column (ethyl acetate/hexane/CH2Cl2, 1:8:3) to give 3-cyano-6-((4-methoxybenzyl)oxy)-1-(2-formylethenyl)benzene (2.8 g) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06350761B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-f7956ba48ff845eba8f2c1eccbc4165e |
| Source note | uspto-grants-2002_02 |