Potassium Carbonate → HCID 86757798, compound

Participants

Reaction Conditions

Reaction Steps

To 4-(N′-(t-butoxycarbonyl)piperidin-4-yl)oxy-3-nitro-N-(3-(3-cyanophenyl)prop-2-en-1-yl)benzenamine (0.39 g) and K2CO3 (0.56 g) in DMF was added methyl bromoacetate. The mixture was stirred at 55° C. for 6 hours. The reaction was cooled, diluted with water and extracted with ethyl acetate (3×). The organic layer was concentrated and purified on silica gel column to afford 4-(N′-(t-butoxycarbonyl)piperidin-4-yl)oxy-3-nitro-N-(methoxycarbonylmethyl)-N-(3-(3-cyanophenyl)prop-2-en-1-yl)benzenamine (0.15 g).

Provenance & Evidence