HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 18318231, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Reactant | HCID 18318131 | HCID 18318131 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18318231 | HCID 18318231 | — |
Reaction Steps
To 4-hydroxy-3-nitro-N-(trifluoromethylcarbonyl)benzenamine (10.0 g), triphenylphosphine (22.1 g) and 4-hydroxy-N-(t-butoxycarbonyl)piperidine (17.0 g) in THF (30 mL) was added DEAD (13.5 mL) drop-wise. The reaction was stirred at ambient temperature for 1 hour, concentrated and purified on silica gel column (ethyl acetate/hexane, gradient) to afford 4-(N′-(t-butoxycarbonyl)piperidin-4-yl)oxy-3-nitro-N-(trifluoromethylcarbonyl)benzenamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06350761B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-125e52dfcfb74f088407658ced17373e |
| Source note | uspto-grants-2002_02 |