Lithium Hydroxide → HCID 136364259, compound

Participants

Reaction Steps

To 4-(piperidin-4-yl)oxy-3-trifluoromethyl-N-(2-(ethoxycarbonyl)ethylcarbonyl)-N-(3-(6-(hydroxy)-3-amidinophenyl)prop-2-en-1-yl)benzenamine (2.0 g) in 100 mL ethanol/H2O (50/50) was added LiOH (0.56 g) at ambient temperature and the resulting solution was stirred at ambient temperature for 4 hours. The reaction was acidified with trifluoroacetic acid, concentrated, separated on HPLC (CH3CN/H2O, gradient) and freeze-dried to afford 4-(piperdin-4-yl)oxy-3-trifluoromethyl-N-(2-(carboxy)ethylcarbonyl)-N-(3-(6-(hydroxy)-3-amidinophenyl)prop-2-en-1-yl)benzenamine.

Provenance & Evidence