Trifluoroacetic acid → HCID 136364260, compound

Participants

Reaction Steps

To 4-(piperidin-4-yl)oxy-3-trifluoromethyl-N-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine (75 mg) in MeOH was added phenyl carbamate (37 mg) and Et3N (0.073 mL). The reaction mixture was stirred at ambient temperature for 3 hours, acidified with trifluoroacetic acid and purified on HPLC (10-40% acetonitrile in water with 0.1% trifluoroacetic acid). The corresponding peak was collected and freezed dried to afford 4-(N′-(aminocarbonyl)piperidin-4-yl)oxy-3-trifluoromethyl-N-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine.

Provenance & Evidence