反应详情

93 mg (0.30 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-5-nitro-1,4-dihydropyridine-3-carboxylic acid, 100 mg (0.75 mmol) of cinnamylamine, 138 mg (0.54 mmol) of 2-chloro-1-methylpyridinium iodide and 0.15 ml (1.08 mmol) of triethylamine were stirred in 5 ml of DMF at room temperature for 2 days. DMF was evaporated under reduced pressure. Ethyl acetate was added to the reaction mixture. After washing with 1 N hydrochloric acid, the organic layer was dried over anhydrous sodium sulfate. After the concentration under reduced pressure, the residue was purified by the silica gel chromatography (hexane/ethyl cetate=4/1) to obtain the title compound.

1. customDMF was evaporated under reduced pressure
2. additionEthyl acetate was added to the reaction mixture
3. washAfter washing with 1 N hydrochloric acid
4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
5. concentrationAfter the concentration under reduced pressure
6. customthe residue was purified by the silica gel chromatography (hexane/ethyl cetate=4/1)