Hydrochloric Acid → 2,6-Dimethyl-4-(4-nitrophenyl)-5-[(3-phenyl-2-propene-1-yl)carbamoyl]-1,4-dihydropyridine-3-carboxylic acid

Participants

Reaction Steps

396 mg (0.814 mmol) of 2-cyanoethyl 2,6-dimethyl-4-(4-nitrophenyl)-5-[(3-phenyl-2-propene-1-yl)carbamoyl]-1,4-dihydropyridine-3-carboxylate was dissolved in 10 ml of methanol. 0.895 ml of 1 N aqueous sodium hydroxide solution was added to the solution, and they were stirred at room temperature overnight. 1 N hydrochloric acid was added to the reaction mixture and then methanol was evaporated under reduced pressure. Water was added to the residue, and a precipitate thus obtained was taken by the filtration. The product was washed with water and then with hexane/ethyl acetate (3:1) and dried under reduced pressure to obtain the title compound.

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