Triethylamine → HCID 70157088, compound

Participants

Reaction Steps

221 mg (0.610 mmol) of 3-pyridine-4-yl-allylamine and 200 mg (0.554 mmol) of mono(2-cyanoethyl) 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate were dissolved in 10 ml of DMF. 159 mg (0.831 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 123 mg (1.22 mmol) of triethylamine were added to the obtained solution under cooling with ice, and they were stirred at room temperature for 2 days. DMF was evaporated under reduced pressure. After the extraction with a saturated aqueous sodium hydrogencarbonate solution and ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was purified by the silica gel chromatography (dichloromethane/methanol=100/1 to 10/1) to obtain the title compound.

Provenance & Evidence