Boron tribromide → HCID 18318016, compound

HRID 1700364Notes

Reaction equation

HRID 1700364 reaction equation
B(Br)(Br)Br.Cl.C[O:7][C:8]1[CH:9]=[C:10]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16]1[CH:15]([C:21]3([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:24][CH2:23][CH2:22]3)[NH:14][CH2:13][CH2:12][C:11]2=1.[Cl-].[NH4+]>ClCCl>[OH:7][C:8]1[CH:9]=[C:10]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16]1[CH:15]([C:21]3([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:22][CH2:23][CH2:24]3)[NH:14][CH2:13][CH2:12][C:11]2=1

Participants

5

Reactant 3

HCID 25134Boron tribromideHCID 25517Ammonium ChlorideHCID 18317860HCID 18317860, compound

Product 1

HCID 18318016HCID 18318016, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

12 ml of 1M boron tribromide in dicloromethane are added at −30° C., under an inert atmosphere, to a solution of 2 g of the compound obtained in Example 7 in 50 ml of dichloromethane. After reaction for two hours at ambient temperature, the reaction mixture is hydrolysed with 1 ml of a saturated ammonium chloride solution. The precipitate obtained is filtered off, washed with water and then dried, enabling the expected product to be isolated.

Workup

  1. customAfter reaction for two hours at ambient temperature
  2. customThe precipitate obtained
  3. filtrationis filtered off
  4. washwashed with water
  5. customdried
  6. customto be isolated

Sources & evidence

ORD record
ord-9b045bcc1fcb4ffd8cdb54d50232d226
Source dataset
uspto-grants-2002_02
Patent number
US06350757B1

Reaction notes

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