Acetyl chloride → 1-(2-Acetyl-6-chloro-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)cyclobutanecarboxylic Acid
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([C:19]([OH:21])=[O:20])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1.[C:22](Cl)(=[O:24])[CH3:23]>>[C:22]([N:8]1[CH2:7][CH2:6][C:5]2[C:4]3[C:12](=[CH:13][CH:14]=[C:2]([Cl:1])[CH:3]=3)[NH:11][C:10]=2[CH:9]1[C:15]1([C:19]([OH:21])=[O:20])[CH2:16][CH2:17][CH2:18]1)(=[O:24])[CH3:23]Participants
3
Procedure
The procedure is as in Example 55, using as substrate the compound of Example 32 and as reagent acetyl chloride.
Sources & evidence
- ORD record
- ord-82c2b0c896c643e598d3243b83847d2d
- Source dataset
- uspto-grants-2002_02
- Patent number
- US06350757B1
Reaction notes
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