Ethyl chloroformate → Ethyl 1-[1-(aminocarbonyl)cyclobutyl]-6-chloro-1,3,4,9-tetrahydro-2H-beta-carboline-2-carboxylate

Participants

Reaction Steps

0.3 ml of ethyl chloroformate, and then 0.2 ml of a 28% ammonium hydroxide solution, are added at −10° C. to a solution of 1 g of the compound of Example 32 in 50 ml of tetrahydrofuran and 0.5 ml of N-methylmorpholine. After reaction for 12 hours, the solvent is distilled off; the residue is then taken up in a water/dichloromethane mixture. The expected product is isolated by decanting, drying and concentrating under reduced pressure.

Provenance & Evidence