Benzyl Bromide → HCID 18317750, compound

Participants

Reaction Steps

To a suspension of 60% sodium hydride (0.18 g, washed with hexane thrice) in dimethylformamide (10 ml) was added 6-phenyl-4,5,6,7-tetrahydroindol-4-one (0.8 g), and the mixture was stirred at room temperature for 30 minutes. To the mixture was added a solution of benzyl bromide (0.71 g) in dimethylformamide (3 ml), and the mixture was stirred at the same temperature for 2.5 hours. Under reduced pressure, the solvent was evaporated, and the residue was dissolved in ethyl acetate. The solution was washed with water and saturated brine, dried with magnesium sulfate and concentrated under reduced pressure, and the residue was purified with silica gel column chromatography (EtOAc/hexane) and recrystallized from ethyl acetate-isopropylether to give colorless crystals of 1-benzyl-6-phenyl-4,5,6,7-tetrahydroindol-4-one (0.86 g).

Provenance & Evidence