Hydrazine hydrate hydrazine hydrate → HCID 18317305, compound

HRID 1700455Notes

Reaction equation

HRID 1700455 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][C:12](=O)[CH:11]([C:15](=O)[CH2:16][CH3:17])[C:10](=[O:19])[CH2:9]1.O.[NH2:21][NH2:22].O.NN>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][C:12]2[NH:22][N:21]=[C:15]([CH2:16][CH3:17])[C:11]=2[C:10](=[O:19])[CH2:9]1

Participants

4

Reactant 2

HCID 18317406Hydrazine hydrate hydrazine hydrateHCID 18317670HCID 18317670, compound

Product 1

HCID 18317305HCID 18317305, compoundYield 142.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-(2-chlorophenyl)-2-propionylcyclohexane-1,3-dione (0.6 g) and hydrazine hydrate hydrazine hydrate (0.12 g) in ethanol (20 ml) was refluxed for 2 hours. Under reduced pressure, the solvent was evaporated, and the residue was recrystallized from ethyl acetate-hexane to give colorless crystals of 6-(2-chlorophenyl)-3-ethyl-4,5,6,7-tetrahydroindazol-4-one (0.47 g).

Workup

  1. customUnder reduced pressure, the solvent was evaporated
  2. customthe residue was recrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-5033f378804e4efbaad012be80f63326
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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