反应详情

To a solution of 4-chloro-7-phenyl-5,6,7,8-tetrahydroquinolin-5-one (0.23 g) in methanol (20 ml) was added sodium methoxide (0.096 g), and the mixture was refluxed for 1 hour and cooled. The solvent was evaporated, and to the residue was added ethyl acetate. The organic layer was washed with water and saturated brine, dried with magnesium sulfate and concentrated under reduced pressure, and the residue was recrystallized from ethyl acetate-hexane to give crystals of 4-methoxy-7-phenyl-5,6,7,8-tetrahydroquinolin-5-one (0.21 g).

1. temperaturethe mixture was refluxed for 1 hour
2. temperaturecooled
3. customThe solvent was evaporated
4. additionto the residue was added ethyl acetate
5. washThe organic layer was washed with water and saturated brine
6. dry with materialdried with magnesium sulfate
7. concentrationconcentrated under reduced pressure
8. customthe residue was recrystallized from ethyl acetate-hexane