5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione → 2,2-Dimethyl-5-[(3-oxo-5-(2-chlorophenyl)-1-cyclohexenylamino)methylene]-[1,3]dioxane-4,6-dione

HRID 1700509Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700509
CO[CH:3]=[C:4]1[C:9](=[O:10])[O:8][C:7]([CH3:12])([CH3:11])[O:6][C:5]1=[O:13].[NH2:14][C:15]1[CH2:20][CH:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:27])[CH2:18][C:17](=[O:28])[CH:16]=1>C(#N)C>[CH3:12][C:7]1([CH3:11])[O:6][C:5](=[O:13])[C:4](=[CH:3][NH:14][C:15]2[CH2:20][CH:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[Cl:27])[CH2:18][C:17](=[O:28])[CH:16]=2)[C:9](=[O:10])[O:8]1

Komponenten

4

Edukt 2

HCID 1521115-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 98593161-Amino-5-(2-chlorophenyl)cyclohexen-3-one

Produkt 1

HCID 110251952,2-Dimethyl-5-[(3-oxo-5-(2-chlorophenyl)-1-cyclohexenylamino)methylene]-[1,3]dioxane-4,6-dioneAusbeute 49,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a solution of 5-methoxymethylene-2,2-dimethyl-[1,3]dioxane-4,6-dione (1.7 g) in acetonitrile (15 ml) was added 1-amino-5-(2-chlorophenyl)cyclohexen-3-one (2.2 g), and the mixture was stirred at room temperature for 13 hours. Precipitated crystals were filtered and washed with acetonitrile to give colorless crystals of 2,2-dimethyl-5-[(3-oxo-5-(2-chlorophenyl)-1-cyclohexenylamino)methylene]-[1,3]dioxane-4,6-dione (1.7 g).

Aufarbeitung

  1. customPrecipitated crystals
  2. filtrationwere filtered
  3. washwashed with acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-7817584f8be9418cbf85776ac61894e2
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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