Butyn-2-one → HCID 10911572, compound

Participants

Reaction Steps

To a mixture of 5-phenylcyclohexane-1,3-dione (1.2 g) and ammonium acetate (0.49 g) in ethanol (30 ml) was added 3-butyn-2-one (0.44 g), and the mixture was stirred at room temperature for 1.5 hours and refluxed for 18 hours. Under reduced pressure, the solvent was evaporated, and the residue was dissolved in ethyl acetate. The solution was washed with sodium hydrogen carbonate solution, water and saturated brine, dried with magnesium sulfate and concentrated under reduced pressure, and the residue was purified with silica gel column chromatography (EtOAc/hexane) to give colorless crystals of 2-methyl-7-phenyl-5,6,7,8-tetrahydroquinolin-5-one (0.88 g).

Provenance & Evidence