Benzenesulfonic Acid → HCID 178434179, compound

HRID 1700547Notes

Reaction equation

HRID 1700547 reaction equation
[NH:1]([N:5]=[C:6]1[CH2:14][CH:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[CH2:12][C:11]2[NH:10][N:9]=[C:8]([CH3:22])[C:7]1=2)[C:2]([NH2:4])=[NH:3].[C:23]1([S:29]([OH:32])(=[O:31])=[O:30])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(O)C>[C:23]1([S:29]([OH:32])(=[O:31])=[O:30])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[NH:1]([N:5]=[C:6]1[CH2:14][CH:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[CH2:12][C:11]2[NH:10][N:9]=[C:8]([CH3:22])[C:7]1=2)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 7371Benzenesulfonic AcidHCID 178434177HCID 178434177, compound

Product 1

HCID 178434179HCID 178434179, compoundYield 86.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-guanidinoimino-6-(2-chlorophenyl)-3-methyl-4,5,6,7-tetrahydroindazole (0.3 g) in ethanol (10 ml) was added benzenesulfonic acid (0.18 g), and the mixture was concentrated. The resulting crystals were recrystallized from water-ethanol to give 4-guanidinoimino-6-(2-chlorophenyl)-3-methyl-4,5,6,7-tetrahydroindazole benzenesulfonate (Compound 23) (0.39 g).

Workup

  1. concentrationthe mixture was concentrated
  2. customThe resulting crystals were recrystallized from water-ethanol

Sources & evidence

ORD record
ord-9589355e04cb4b388f70f8036c712013
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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