Hydrochloric Acid → HCID 178431134, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3-methyl-6-(2-trifluoromethylphenyl)-4,5,6,7-tetrahydrobenzofuran-4-one (0.28 g) and aminoguanidine hydrochloride (105 mg) were added ethanol (20 ml) and 6N hydrochloric acid (0.082 ml), and the mixture was stirred at 90° C. for 2 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-4-guanidinoimino-3-methyl-6-(2-trifluoromethylphenyl)-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 39) (0.21 g).

Provenance & Evidence