Hydrochloric Acid → 2-[(E)-[6-(furan-2-yl)-3-methyl-6,7-dihydro-5H-1-benzofuran-4-ylidene]amino]guanidine;hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a mixture of 6-(2-furyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-one (0.22 g) and aminoguanidine hydrochloride (113 mg) were ethanol (20 ml) and 6N hydrochloric acid (0.088 ml), and the mixture was stirred at 90° C. for 2 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-6-(2-furyl)-4-guanidinoimino-3-methyl-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 47) (0.22 g).

Provenance & Evidence