Hydrochloric Acid → HCID 178432667, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 7-(2-chlorophenyl)-2,4-dimethyl-5,6,7,8-tetrahydroquinazolin-5-one (0.20 g) and aminoguanidine hydrochloride (77 mg) were added ethanol (14 ml) and 6N hydrochloric acid (0.12 ml), and the mixture was stirred at 90° C. for 3 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-7-(2-chlorophenyl)-5-guanidinoimino-2,4-dimethyl-5,6,7,8-tetrahydroquinazoline hydrochloride (Compound 90) (0.14 g).

Provenance & Evidence