Hydrochloric Acid → 5-Guanidinoimino-4-methyl-7-(3-thienyl)-5,6,7,8-tetrahydroquinoline hydrochloride

Participants

Reaction Steps

A mixture of 4-methyl-7-(3-thienyl)-5,6,7,8-tetrahydroquinolin-5-one (243 mg), aminoguanidine hydrochloride (122 mg) and concentrated hydrochloric acid (0.2 ml) in ethanol (3 ml) was refluxed for 2 hours. The reaction solution was cooled, and precipitated crystals were filtered, washed with ethanol and dried to give 5-guanidinoimino-4-methyl-7-(3-thienyl)-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 100) (362 mg) as colorless crystals.

Provenance & Evidence