反应详情

A solution of 5-(2,5-dichlorothiophen-3-yl)-2-(1-hydroxyethylidene)cyclohexane-1,3-dione (2.48 g) and hydrazine hydrate (0.508 g) in ethanol (10 ml) was refluxed for 2 hours. Under reduced pressure, the solvent was evaporated, and to the residue was added water. The mixture was extracted with ethyl acetate, and the organic layer was washed with water and concentrated under reduced pressure. The residue was washed with diisopropylether to give 6-(2,5-dichlorothiophen-3-yl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (2.15 g) as pale yellow crystals.

1. customUnder reduced pressure, the solvent was evaporated
2. additionto the residue was added water
3. extractionThe mixture was extracted with ethyl acetate
4. washthe organic layer was washed with water
5. concentrationconcentrated under reduced pressure
6. washThe residue was washed with diisopropylether