HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1700649Generated: November 1, 2026
Methyl acetoacetate → 4-Methyl-7-(thiophen-3-yl)-1,2,5,6,7,8-hexahydroquinoline-2,5-dione
https://huagongshe.com/reaction/1700649
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | 1-Amino-5-(3-thienyl)cyclohexen-3-one | HCID 18317508 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Methyl-7-(thiophen-3-yl)-1,2,5,6,7,8-hexahydroquinoline-2,5-dione | HCID 18317557 | 22% |
Reaction Steps
A mixture of 1-amino-5-(thiophen-3-yl)cyclohexen-3-one (4.75 g) and methyl acetoacetate (10 g) was stirred at 170° C. for 18 hours and cooled, and to the mixture was added ethyl acetate. Precipitated crystals were filtered and washed with ethyl acetate to give 4-methyl-7-(thiophen-3-yl)-1,2,5,6,7,8-hexahydroquinoline-2,5-dione (1.4 g) as yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06350749B1 |
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| Source dataset | uspto-grants-2002_02 |
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| ORD ID | ord-00e072b0c1ba4d299b7579ece82677b5 |
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| Source note | uspto-grants-2002_02 |
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