反应详情

温度

50 °C

In methanol (390 ml) was suspended (±)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (39.0 g), and to the suspension was added dropwise a solution of 28% sodium methoxide in methanol. The mixture was stirred at 50° C. for 1 hour. Under reduced pressure, the mixture was concentrated, and the obtained crystals were washed with water and dried to give (±)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (Compound 108) (32.8 g).

1. concentrationUnder reduced pressure, the mixture was concentrated
2. washthe obtained crystals were washed with water
3. customdried