Sulfuric Acid → HCID 178428127, compound

HRID 1700658Notes

Reaction equation

HRID 1700658 reaction equation
[Cl:1][C:2]1[S:3][C:4]([Cl:23])=[CH:5][C:6]=1[CH:7]1[CH2:16][C:15]2[N:14]=[CH:13][CH:12]=[C:11]([CH3:17])[C:10]=2[C:9](=[N:18][NH:19][C:20]([NH2:22])=[NH:21])[CH2:8]1.[S:24](=[O:28])(=[O:27])([OH:26])[OH:25]>C(O)C>[S:24](=[O:26])(=[O:25])([OH:28])[OH:27].[Cl:1][C:2]1[S:3][C:4]([Cl:23])=[CH:5][C:6]=1[CH:7]1[CH2:16][C:15]2[N:14]=[CH:13][CH:12]=[C:11]([CH3:17])[C:10]=2[C:9](=[N:18][NH:19][C:20]([NH2:22])=[NH:21])[CH2:8]1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 178428123HCID 178428123, compound

Product 1

HCID 178428127HCID 178428127, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (0.8 g) in ethanol (20 ml) was added 0.5M sulfuric acid (3.9 ml), and the mixture was concentrated under reduced pressure to give crystals, which were recrystallized from water and washed with ethanol to give (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline sulfurate (Compound 115) (0.8 g).

Workup

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customto give crystals, which
  3. customwere recrystallized from water
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-0de4d88b551b44aea74e7272a4c16818
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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