反应详情

To a solution of (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (0.8 g) in ethanol (20 ml) was added 0.5M sulfuric acid (3.9 ml), and the mixture was concentrated under reduced pressure to give crystals, which were recrystallized from water and washed with ethanol to give (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline sulfurate (Compound 115) (0.8 g).

1. concentrationthe mixture was concentrated under reduced pressure
2. customto give crystals, which
3. customwere recrystallized from water
4. washwashed with ethanol