HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Acetate → 1-Amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 5-(2-Fluoro-5-methylphenyl)cyclohexane-1,3-dione | HCID 18317431 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one | HCID 18317623 | 87.1% |
Reaction Steps
A solution of 5-(2-fluoro-5-methylphenyl)cyclohexane-1,3-dione (1.5 g) and ammonium acetate (1.6 g) in ethanol (23 ml) was refluxed for 20 hours. Under reduced pressure, the solvent was evaporated, and precipitated crystals were washed with water and toluene, and dried to give 1-amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one (1.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06350749B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-15bf297343ad43148504d34913f2ae9b |
| Source note | uspto-grants-2002_02 |