Acetone → HCID 54328304, compound

HRID 1700709Notes

Reaction equation

HRID 1700709 reaction equation
[OH-].[Na+].[CH3:3][C:4]([CH3:6])=[O:5].[Cl:7][C:8]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:9]=1[CH:10]=O>O>[Cl:7][C:8]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:9]=1[CH:10]=[CH:3][C:4](=[O:5])[CH3:6]

Participants

5

Reactant 3

HCID 180AcetoneHCID 14798Sodium HydroxideHCID 807022,5-Dichlorobenzaldehyde

Product 1

HCID 54328304HCID 54328304, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In water (500 ml) was dissolved sodium hydroxide (4.0 g), and to the mixture was added acetone (100 ml), and then 2,5-dichlorobenzaldehyde (15.9 g). The mixture was stirred at room temperature for 1 hour, and acetone was evaporated under reduced pressure. The residue was extracted with ethyl acetate, and the organic layer was washed with water and saturated brine, and concentrated under reduced pressure to give 4-(2,5-dichlorophenyl)-3-buten-2-one (19.0 g).

Workup

  1. customacetone was evaporated under reduced pressure
  2. extractionThe residue was extracted with ethyl acetate
  3. washthe organic layer was washed with water and saturated brine
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-53f922b8150443ebb3662317442ca6f9
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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