Acetone → HCID 54115009, compound

HRID 1700723Notes

Reaction equation

HRID 1700723 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:5]=[CH:6][C:7]([O:12][CH3:13])=[C:8]([CH:11]=1)[CH:9]=O.[CH3:14][C:15]([CH3:17])=[O:16]>O>[F:3][C:4]1[CH:5]=[CH:6][C:7]([O:12][CH3:13])=[C:8]([CH:9]=[CH:14][C:15](=[O:16])[CH3:17])[CH:11]=1

Participants

5

Reactant 3

HCID 180Acetone2×HCID 14798Sodium HydroxideHCID 27349435-Fluoro-2-methoxybenzaldehyde

Product 1

HCID 54115009HCID 54115009, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In water (200 ml) was dissolved sodium hydroxide (3 g), and to the solution was added acetone (80 ml) and then was added dropwise a solution of 5-fluoro-2-methoxybenzaldehyde (10 g) in acetone (25 ml). The reaction solution was stirred at room temperature for 4 hours, and acetone was evaporated under reduced pressure. The residue was extracted with ethyl acetate, and the organic layer was washed with water and saturated brine and concentrated under reduced pressure to give 4-(5-fluoro-2-methoxyphenyl)-3-buten-2-one (13 g).

Workup

  1. customacetone was evaporated under reduced pressure
  2. extractionThe residue was extracted with ethyl acetate
  3. washthe organic layer was washed with water and saturated brine
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-e85a8779626c4b338b51af66c6674ee4
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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