Sodium Methoxide → HCID 178428118, compound

HRID 1700728Notes

Reaction equation

HRID 1700728 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[CH:10]1[CH2:19][C:18]2[N:17]=[CH:16][CH:15]=[C:14]([CH3:20])[C:13]=2[C:12](=[N:21][NH:22][C:23]([NH2:25])=[NH:24])[CH2:11]1.C[O-].[Na+]>CO>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[CH:10]1[CH2:19][C:18]2[N:17]=[CH:16][CH:15]=[C:14]([CH3:20])[C:13]=2[C:12](=[N:21][NH:22][C:23]([NH2:25])=[NH:24])[CH2:11]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 178428119HCID 178428119, compound

Product 1

HCID 178428118HCID 178428118, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
50 °C

Procedure

To a solution of (±)-7-(2,5-dichlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (3.0 g) in methanol (50 ml) was added a solution of 28% sodium methoxide in methanol (2.7 g), and the mixture was stirred at 50° C. for 1 hour. Under reduced pressure, the solvent was evaporated, and to the residue was added water. Precipitated crystals were washed with water and dried to give (±)-7-(2,5-dichlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline.

Workup

  1. customUnder reduced pressure, the solvent was evaporated
  2. additionto the residue was added water
  3. customPrecipitated crystals
  4. washwere washed with water
  5. customdried

Sources & evidence

ORD record
ord-ca2ab55c90b34279821bd9b77b54ae73
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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