Boron tribromide → HCID 18317642, compound

Participants

Reaction Steps

To a solution of 1M boron tribromide in dichloromethane (12.3 ml) was added dropwise a solution of 7-(5-chloro-2-methoxyphenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one (1.2 g) in dichloromethane (30 ml) at 0° C. The reaction solution was stirred at room temperature for 1.5 hours, and to the solution were added ice and sodium hydrogen carbonate solution. The mixture was extracted with ethyl acetate, and the organic layer was washed with water and saturated brine, and dried with sodium sulfate. Under reduced pressure, the solvent was evaporated to give 7-(5-chloro-2-hydroxyphenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one.

Provenance & Evidence