Hydrochloric Acid → HCID 178430925, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 7-(5-chloro-2-fluorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one (0.33 g) and aminoguanidine hydrochloride (0.133 g) in ethanol (4 ml) was added concentrated hydrochloric acid (0.1 ml), and the mixture was stirred at 110° C. (bath) for 2 hours. The reaction solution was cooled to room temperature, and the crystals were filtered and dried to give 7-(5-chloro-2-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 175) (0.345 g) as blue gray crystals.

Provenance & Evidence