HCID 18318458, compound → HCID 22949457, compound

HRID 1700770Notes

Reaction equation

[O:1]=[C:2]1[N:6]([C@@H:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C@H:8]2[OH:13])[CH2:5][CH2:4][O:3]1.F[C:15]1[CH:20]=[CH:19][C:18]([C:21]([C:23]2[C:24]3[CH:45]=[CH:44][C:43]([O:46]CC4C=CC=CC=4)=[CH:42][C:25]=3[S:26][C:27]=2[C:28]2[CH:33]=[CH:32][C:31]([O:34][CH2:35][CH2:36][N:37]3[CH2:41][CH2:40][CH2:39][CH2:38]3)=[CH:30][CH:29]=2)=[O:22])=[CH:17][CH:16]=1>>[O:1]=[C:2]1[N:6]([C@@H:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C@H:8]2[O:13][C:15]2[CH:20]=[CH:19][C:18]([C:21]([C:23]3[C:24]4[CH:45]=[CH:44][C:43]([OH:46])=[CH:42][C:25]=4[S:26][C:27]=3[C:28]3[CH:29]=[CH:30][C:31]([O:34][CH2:35][CH2:36][N:37]4[CH2:41][CH2:40][CH2:39][CH2:38]4)=[CH:32][CH:33]=3)=[O:22])=[CH:17][CH:16]=2)[CH2:5][CH2:4][O:3]1

Participants

Reactant 2

HCID 18318458HCID 18318458, compound

HCID 69980669HCID 69980669, compound

Product 1

HCID 22949457HCID 22949457, compoundYield 49%

Procedure

Using a procedure similar to that described below in Example 19, the title compound was prepared in 49% yield from (±)-trans-2-(2-oxooxazolidin-3-yl)cylohexanol (Part A) and 6-benzyloxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-benzo[b]thiophen-3-yl 4-fluorophenyl ketone (Part B).

Sources & evidence

ORD record: ord-17d80cf1f7554c4993b6d04570292355
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06350774B1

Reaction notes

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