Water → HCID 53788886, compound

Participants

Reaction Steps

A 0° C. solution of 11.20 g (29.4 mmol) of (S)-2-(2-oxopyrrolidin-1-yl)propyl tert-butyldiphenylsilyl ether (Part B) in 100 mL of THF was treated with 36.0 mL (36 mmol) of tetrabutylammonium fluoride (1 M in THF). The reaction was stirred at ambient temperature until tic analysis indicated the complete disappearance of starting material (30 min). The reaction was poured into 300 mL of H2O and the mixture extracted with CH2Cl2 (3×300 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo to give 8.40 g of the corresponding (S)-2-(2-oxopyrrolidin-1-yl)propyl alcohol which was used without purification.

Provenance & Evidence