Benzenepropanoic acid, 4-hydroxy-, methyl ester → 3-[4-[3-(N-dodecyl-N-methylamino)propoxy]phenyl]propanoic acid, methyl ester

HRID 1700877Notes

Reaction equation

HRID 1700877 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.[CH2:14]([N:26]([CH2:28][CH2:29][CH2:30]O)[CH3:27])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>>[CH2:14]([N:26]([CH2:28][CH2:29][CH2:30][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:6][CH:7]=1)[CH3:27])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Participants

3

Reactant 2

HCID 79706Benzenepropanoic acid, 4-hydroxy-, methyl esterHCID 131222613-[Dodecyl(methyl)amino]propan-1-OL

Product 1

HCID 867571153-[4-[3-(N-dodecyl-N-methylamino)propoxy]phenyl]propanoic acid, methyl esterYield 68%

Procedure

Methyl 3-(4-hydroxyphenyl)propanoate (1.0 g, 5.5 mmol) and 3-(N-dodecyl-N-methylamino)propanol (1.43 g, 5.5 mmol) were reacted as described in example 1 to give 1.57 g (43%) of title material as an oil.

Sources & evidence

ORD record
ord-232db5686b3a42169ea590dc8a116619
Source dataset
uspto-grants-2002_02
Patent number
US06350892B1

Reaction notes

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