HRID1700898

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCCCCCCCCCN(CCCC(=O)OCC)CCOc1ccc(CCC(=O)C(F)(F)F)cc1

HCID86757122

未命名化合物

结构：CCCCCCCCCCCCN(CCOc1ccc(CCC(O)C(F)(F)F)cc1)CCC(=O)OCC

HCID86757126

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCN(CCOc1ccc(CCC(=O)C(F)(F)F)cc1)CCC(=O)OC

HCID86757815

未命名化合物

收率 69.8%

PROCEDURE

实验过程

3-[N-Dodecyl-N-2-[4-[3-hydroxy-4,4,4-trifluorobutyl]phenoxy]ethylamino]propanoic acid, ethyl ester (320 mg, 0.60 mmol) was oxidized as described in the preparation of 4-[N-dodecyl-N-[2-[4-(3-oxo-4,4,4-trifluorobut-1-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester (Example 48) and afforded the title compound (216 mg, 68%) as a pale yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6de59afcf618480ab099f546e8ed15ef
来源数据集: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06350892B1
来源说明: uspto-grants-2002_02

反应 SMILES

[CH2:1]([N:13]([CH2:31][CH2:32][C:33]([O:35][CH2:36]C)=[O:34])[CH2:14][CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][CH:25]([OH:30])[C:26]([F:29])([F:28])[F:27])=[CH:19][CH:18]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(N(CCCC(OCC)=O)CCOC1C=CC(CCC(=O)C(F)(F)F)=CC=1)CCCCCCCCCCC>>[CH2:1]([N:13]([CH2:31][CH2:32][C:33]([O:35][CH3:36])=[O:34])[CH2:14][CH2:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][C:25](=[O:30])[C:26]([F:27])([F:28])[F:29])=[CH:21][CH:22]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]