HRID1700904

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCCCCCCCCCN(CCCC(=O)OCC)CCOc1ccc(CCC(=O)C(F)(F)F)cc1

HCID86757122

未命名化合物

结构：CCCCCCCCCCCCN1C[C@@H](Oc2ccc(CCC(O)C(F)(F)F)cc2)C[C@H]1C(=O)OC

HCID86757130

未命名化合物

PRODUCTS

生成物

HCID86757816

未命名化合物

收率 64.2%

PROCEDURE

实验过程

(2S, 4S)-1-N-Dodecyl-4-[4-[3-hydroxy-4,4,4-trifluorobutyl]phenoxy]pyrrolidine-2-carboxylic Acid, Methyl Ester (425 mg, 0.825 mmol) was oxidized as described in the preparation of 4-[N-dodecyl-N-[2-[4-(3-oxo-4,4,4-trifluorobut-1-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester and afforded the title compound (272 mg, 64%) as a pale yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7a65c1fb23924708bec5b557b88c8578
来源数据集: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06350892B1
来源说明: uspto-grants-2002_02

反应 SMILES

[CH2:1]([N:13]1[CH2:17][C@@H:16]([O:18][C:19]2[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][CH:27]([OH:32])[C:28]([F:31])([F:30])[F:29])=[CH:21][CH:20]=2)[CH2:15][C@H:14]1[C:33]([O:35][CH3:36])=[O:34])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(N(CCCC(OCC)=O)CCOC1C=CC(CCC(=O)C(F)(F)F)=CC=1)CCCCCCCCCCC>>[CH2:1]([N:13]1[CH2:17][C@@H:16]([O:18][C:19]2[CH:20]=[CH:21][C:22]([CH2:25][CH2:26][C:27](=[O:32])[C:28]([F:29])([F:31])[F:30])=[CH:23][CH:24]=2)[CH2:15][C@H:14]1[C:33]([O:35][CH3:36])=[O:34])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]