反应详情

A mixture of 2-trifluoroacetylphenol (380 mg, 2.0 mmol), 2-[N,N-dimethylamino]ethyl chloride, hydrochloride (432 mg, 6.0 mmol) potassium carbonate (1.38 g, 10 mmol) and toluene (5 ml) was refluxed for 3.5 h. After cooling to r.t., the mixture was treated with water and ether. The organic layer was washed twice with brine, dried over sodium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel (acetone/ether 1:1 to 1:0) to give the title compound (375 mg, 72%) as a white solid.

1. temperaturewas refluxed for 3.5 h
2. washThe organic layer was washed twice with brine
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated in vacuo
5. customThe residue was chromatographed on silica gel (acetone/ether 1:1 to 1:0)