HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-[4-[2-(N-Dodecyl-N-Hexylamino]ethoxy]phenyl]-1,1,1-trifluoro-2-butanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-Hexyl-N-[2-[4-(3,3-dimethoxy-4,4,4-trifluorobut-1-yl)phenoxy]ethyl]dodecylamine | HCID 18319019 | — |
| Reactant | 4-[N-dodecyl-N-[2-[4-(3oxo-4,4,4-trifluorobut-1-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester | HCID 86757122 | — |
| Product | 4-[4-[2-(N-Dodecyl-N-Hexylamino]ethoxy]phenyl]-1,1,1-trifluoro-2-butanone | HCID 18319021 | 78.2% |
Reaction Steps
N-Hexyl-N-[2-[4-(3,3-dimethoxy-4,4,4-trifluorobut-1-yl)phenoxy]ethyl]dodecylamine (353 mg, 0.63 mmol) was treated with trifluoroacetic acid as described in the preparation of 4-[N-dodecyl-N-[2-[4-(4,4,4-trifluoro-3-oxobut-1-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester . The residue was chromatographed on silica gel (dichloromethane/methanol 98:2 to 94:6) to afford the title compound (253 mg, 78%) as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06350892B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-8903069240954f22bf2ea5c367c34aee |
| Source note | uspto-grants-2002_02 |