Potassium Carbonate → HCID 22949948, compound

Participants

Reaction Steps

A solution of 3(4-hydroxyphenyl)-1-(tert-butyldiphenylsilyloxy)propane (3.91 g, 10.0 mmol) and methyl bromoacetate (3.0 g, 19.7 mmol) in acetonitrile (100 ml) was treated with powdered anhydrous potassium carbonate (10 g) and the resulting mixture was heated under reflux for 1 h. The cooled mixture was filtered and the filtrate was concentrated in vacuo. Chromatography of the residue as silica gel (elution toluene-ethyl acetate, 98:2) gave 4.36 g (94%) of the title material as clear oil.

Provenance & Evidence