反应详情

A solution of 0.200 g of compound 34 in 5 ml of acetone/CF3COOH is heated to 35° for 18 h. Trethyl amine (1 ml) is then added to the mixture at 0° followed by 20 ml of diethyl ether. The solution is then three times extracted with 10 ml of water each, dred, and the solvent evaporated. FC of the residue in hexanelether 3/1 (+1% of triethyl amine) gives 0.118 g of 30. MS (C12H22O3; 214): 215 [M+H]. 1H-NMR (CDCl3): δ=4.05-3.80 m (3H); 2.5 q (2H); 1.40 s (3H); 1.30 m (includ. s) (4H); 1.10 s (3H); 1.00 s (3H); 0.95 t (3H).

1. extractionthree times extracted with 10 ml of water each,
2. customthe solvent evaporated