反应详情

2-((1R)-1-(tert-Butoxycarbonylamino)-2-(2-naphthyl)ethyl)-5-phenyl-1,3-thiazole-4-carboxylic acid amide (0.155 g; 0.327 mmol) was dissolved in methylene chloride (4 ml) and trifluoroacetic acid (4 ml) was added. The reaction mixture was stirred 1 hour at room temperature and the solvent was removed in vacuo. The residue was dissolved in methylene chloride and evaporated (2×2 ml). The residue was dissolved in diethyl ether (2 ml). Hydrochloric acid (1 N; 3 ml) and methanol (10 ml) were added. The solvent was removed in vacuo to afford 0.106 g of 2-((1R)-1-amino-2-(2-naphthyl)-ethyl)-5-phenyl-1,3-thiazole-4-carboxylic acid amide.

1. customthe solvent was removed in vacuo
2. dissolutionThe residue was dissolved in methylene chloride
3. customevaporated (2×2 ml)
4. dissolutionThe residue was dissolved in diethyl ether (2 ml)
5. additionHydrochloric acid (1 N; 3 ml) and methanol (10 ml) were added
6. customThe solvent was removed in vacuo