Phenol → HCID 86736852, compound

Participants

Reaction Steps

To a well stirred solution of 1.6 g of chlorosulfonyl isocyanate in 7 ml of dry xylene at ambient temperature and pressure was added 0.9 g of phenol. The resulting mixture was heated to reflux temperature for 1.5 hours. The solvent was removed under reduced pressure to give a clear oil. The oil was diluted with 5 ml of methylene chloride and added to a cooled (ice-water bath) suspension of 1.5 g of 2-amino-4.6-dimethoxypyrimidine in 10 ml of methylene chloride. The solvent was removed under vacuum. The resultant oil was triturated with 1-chlorobutane and filtered to yield 2.6 g of white solid, m.p. 136°-139° C. The infrared spectrum showed characteristic absorption bands at 3150 cm-1, 1720 cm-1, 1625 cm-1, 1580 cm-1.

Provenance & Evidence