Ammonia → 2,6-Diethyl-2,3,6-trimethylpiperidin-4-amine

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Reaction Steps

197.3 g of 2,6-diethyl-2,3,6-trimethylpiperidin-4-one are dissolved in 1.5 liters of methanol which is saturated with ammonia. This solution is hydrogenated in a 3 liter-autoclave at a hydrogen pressure of 100 bar in the presence of 30 g of Raney nickel. After 24 hours, the solution is filtered and the solvent evaporated. The residue is distilled in vacuo yielding 162 g 2,6-diethyl-2,3,6-trimethyl-4-aminopiperidine (compound no. 1) distilling at 133°-35° C. at 23 mm Hg. Using a methanolic solution of methylamine, n-butylamine, n-hexylamine, n-dodecylamine, benzylamine and 2-amino-ethanol, respectively, instead of the ammonia solution while otherwise following the procedure described above, there are obtained:

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