Methyl iodide → HCID 20348469, compound

Participants

Reaction Steps

A mixture of 1.43 g. of 6-allyl-α-(2,4-diamino-5-pyrimidyl)-5-methoxy-m-cresol, 5 ml. of 1-N potassium hydroxide and 300 ml. of 40% aqueous methanol was treated with 0.32 ml. of methyl iodide and stirred at room temperature for 48 hours. The methanol was removed by distillation and the residue was extracted with ethyl acetate. Working-up of the ethyl acetate extract yielded 5-(4-allyl-3,5-dimethoxybenzyl)-2,4-diaminopyrimidine of melting point 185°-187° C. (from methanol) in a yield of 75%.

Provenance & Evidence