Potassium Hydroxide → HCID 20348753, compound

HRID 1701157Notes

Reaction equation

HRID 1701157 reaction equation
C[O:2][C:3](=[O:22])[CH2:4][S:5][CH:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[CH:11][CH:10]=1)[CH2:7][CH3:8].[OH-].[K+].C1CCCCC1.C(OCC)(=O)C>C(O)C.O>[F:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:12]1[CH:13]=[CH:14][C:9]([CH:6]([S:5][CH2:4][C:3]([OH:22])=[O:2])[CH2:7][CH3:8])=[CH:10][CH:11]=1

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 21867204Cyclohexane ethylacetateHCID 53654790HCID 53654790, compound

Product 1

HCID 20348753HCID 20348753, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

220 gm of the methyl ester obtained in Example B were hydrolized with 58.2 gm of potassium hydroxide in 900 ml of ethanol by boiling for one hour. Subsequently, the mixture was diluted with 1800 ml of water, the neutral components were extracted with ether, and the free acid was precipitated from the alkaline phase. By extraction with ether, and washing, drying and evaporating the ethereal extract, the reaction product was isolated. Yield: 130 gm (62% of theory); oil, Rf -value: 0.7 (cyclohexane-ethyl acetate=1:1 on silicagel-polygram-plates).

Workup

  1. extractionthe neutral components were extracted with ether
  2. customthe free acid was precipitated from the alkaline phase
  3. extractionBy extraction with ether
  4. washwashing
  5. customdrying
  6. customevaporating the ethereal
  7. extractionextract
  8. customthe reaction product was isolated

Sources & evidence

ORD record
ord-bfb861dd541443c2af60f15dd790345d
Source dataset
uspto-grants-1980_03
Patent number
US04191776

Reaction notes

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