Sodium Hydroxide → 4-Amino-5,6-dihydro-1-benzothiophen-7(4H)-one

HRID 1701217Notes

Reaction equation

HRID 1701217 reaction equation
Cl.[O:2]=[C:3]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[CH:6]([NH2:12])[CH2:5][CH2:4]1.[OH-].[Na+]>O>[O:2]=[C:3]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[CH:6]([NH2:12])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 233477954,5,6,7-Tetrahydro-7-oxobenzo[b]thiophen-4-amine hydrochloride

Product 1

HCID 233477964-Amino-5,6-dihydro-1-benzothiophen-7(4H)-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The free amine is obtained by neutralizing the amine hydrochloride in water with sodium hydroxide solution. It is separated by extraction with CHCl3 and removal of the CHCl3 in vacuo affords 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophen-4-amine.

Workup

  1. customIt is separated by extraction with CHCl3 and removal of the CHCl3 in vacuo

Sources & evidence

ORD record
ord-76ec2cee971846269eaff9506b80f602
Source dataset
uspto-grants-1980_03
Patent number
US04191830

Reaction notes

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